The world model
Learns shared representations across sequence, structure, function, cell state and imaging, so evidence in one modality can inform predictions in another.
Microsoft Research built Quine to model biology as one connected system, from genes and proteins to cells, tissues and patients. QUINE turns that research into something you can explore, play with and question.
Contract address
Robinhood Chain
- Announced September 29, 2026 by Microsoft Research, with the Broad Institute as a lab partner.
- One model, many modalities: genomics, proteins, chemistry, RNA and cell state, and bioimaging, trained together.
- One weekend to narrow thousands of compounds to a lab-ready shortlist in pancreatic cancer.
Make your Quine PFP
Upload a photo or grow a new cell, then pick the cell state it takes on.
Drag the photo to reposition it.
Quine Super Intelligence(SI) explorer
Everything Microsoft Research has published about Quine, organized so you can move through it.
Step 1 of 5
A scientist asks a question
The harness
Connects the model to reasoning models, scientific tools, the literature and the lab, helping researchers break a question into steps and revise the plan.
The research program
Microsoft scientists, Fellows, collaborators and lab partners test Quine on real biological questions and feed results back in.
Bars show the approximate range of biological scale each modality observes. Select one to see what it adds.
Classical 0%
Basal 0%
Third state 0%
Pancreatic tumor cells sit in two known states. Apply a treatment to see how Quine's predictions played out.
Interactive illustration of the published findings. Cell counts are simulated.
Pancreatic ductal adenocarcinoma
The most common form of pancreatic cancer, and one of the hardest to treat. With the Broad Institute, Microsoft tested whether a tumor's transcriptional cell state, not only its genetics, can be a drug target.
- Screen. Quine scored thousands of compounds on how likely they were to move tumor cells between therapeutically relevant states.
- Shortlist. The search went from thousands of compounds to a handful of lab candidates in one weekend.
- Classical to basal. Quine's highest-ranked compounds produced the largest intended shifts across lab assays, some through unexpected mechanisms.
- Basal to classical. The reverse shift was harder, and Quine had predicted the weaker effect.
- A third state. Quine predicted some compounds would push cells into a distinct third phenotype. The lab confirmed it.
Quine Fellows program
A 16-week research fellowship with financial support, hosted by Microsoft Research in Cambridge, MA. Fellows work with Microsoft researchers and get access to Quine and computing resources, with experimental support where it fits the project.
- Applications
- September 29 to November 2, 2026
- Fellowship
- June 7 to September 24, 2027
- Open to
- PhD candidates, postdocs, research scientists, academic and independent researchers
Areas of interest
- Protein design and engineering
- Enzyme design, discovery and optimization
- Genetic and chemical perturbation of cell state
- Early-stage therapeutic research in under-resourced disease areas
- Adjacent problems where faster design and experiment cycles could change the outcome
Quine SI
Grounded in Quine's research. Ask anything.